Article
High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2017
Roy Bishnudeo, Neumann Ralf S, Snir Omri, Iversen Rasmus, Sandve Geir Kjetil, Lundin Knut E A, Sollid Ludvig M
Abstract excerpt
Characterization of Ag-specific BCR repertoires is essential for understanding disease mechanisms involving humoral immunity. This is optimally done by interrogation of paired H chain V region (VH) and L chain V region (VL) sequences of individual and Ag-specific B cells. By applying single-cell high-throughput sequencing on gut lesion plasma cells (PCs), we have analyzed the transglutaminase 2 (TG2)-specific...
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