Back to search

Article

BDNF overexpression in the ventral hippocampus promotes antidepressant- and anxiolytic-like activity in serotonin transporter knockout rats

2020-07-01

Abstract excerpt

Brain-derived neurotrophic factor is one of the most studied proteins playing a pivotal role in neuroplasticity events and vulnerability and resilience to stress-related disorders. Most importantly, BDNF is decreased in depressive patients, and increased after antidepressant treatment. Additionally, BDNF was found to be reduced in a genetic subset of depression susceptible patients carrying the human polymorphism...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
da1c40e7-8882-5595-8208-bcf7123b3ba2
DOI
10.1101/2020.07.01.181966
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
BDNF overexpression in the ventral hippocampus promotes antidepressant- and anxiolytic-like activity in serotonin transporter knockout ratsDOI 10.1101/2020.07.01.181966
BDNF Overexpression in the Prelimbic Cortex Does Not Reduce Anxiety- and Depression-like Behavior in Serotonin Knockout RatsSemantic proximity
Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans.Semantic proximity
Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice.Semantic proximity
Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress.Semantic proximity
Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion.Semantic proximity
Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used.Semantic proximity
Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors.Semantic proximity
Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment.Semantic proximity
The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male miceSemantic proximity
The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice.Semantic proximity
Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.Semantic proximity
Select a neighboring publication to make it the new centre.