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Article

Dynamic expression of PTSD-like behavioral and corticosterone phenotypes over time in a peripubertal rat model: Modulation by fluoxetine.

Physiology & behavior - 1 Sept 2026

Voronina Alla, Bondarenko Larysa, Karatsuba Tetiana, Munko Maksim, Blazhchuk Iryna, Kovalenko Valentina, Shayakhmetova Ganna

Abstract excerpt

Post-traumatic stress disorder (PTSD) frequently emerges following early-life trauma, yet the temporal dynamics of PTSD-like phenotypes and their pharmacological modulation during development remain poorly understood. In the present study, we investigated time-dependent behavioral and endocrine alterations in a peripubertal rat stress-restress model and assessed the effects of fluoxetine across early and delayed...

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PMID: 42069276
DOI: 10.1016/j.physbeh.2026.115363

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