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Article

Increased Power for Detection of Parent-of-Origin Effects via the Use of Haplotype Estimation.

American journal of human genetics - 3 Sept 2015

Howey Richard, Mamasoula Chrysovalanto, Töpf Ana, Nudel Ron, Goodship Judith A, Keavney Bernard D, Cordell Heather J

Abstract excerpt

Parent-of-origin (or imprinting) effects relate to the situation in which traits are influenced by the allele inherited from only one parent and the allele from the other parent has little or no effect. Given SNP genotype data from case-parent trios, the parent of origin of each allele in the offspring can often be deduced unambiguously; however, this is not true when all three individuals are heterozygous. Most...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26320892
DOI: 10.1016/j.ajhg.2015.07.016
PMCID: PMC4564992

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