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Article

Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.

Neuroscience - 13 Aug 2008

Chen G-L, Miller G M

Abstract excerpt

Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal 5-HT and its genetic variance is associated with numerous behavioral traits and psychiatric disorders. This study characterized the functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2 (mTPH2). Four haplotypes of mTPH2 were cloned into pcDNA3.1 and stably transfected into PC12 cells. The...

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Identifiers

PMID: 18593594
DOI: 10.1016/j.neuroscience.2008.05.050
PMCID: PMC2644555

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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