Article
Immunohistochemical Investigation of BRAF p.V600E mutations in thyroid carcinoma using 2 separate BRAF antibodies.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2014
Fisher Kevin E, Neill Stewart G, Ehsani Laleh, Caltharp Shelley A, Siddiqui Momin T, Cohen Cynthia
Abstract excerpt
BACKGROUND: Approximately 45% of papillary thyroid carcinomas harbor BRAF p.V600E mutations and current practice algorithms endorse molecular testing for BRAF p.V600E. We assessed the utility of immunohistochemistry to detect BRAF p.V600E mutations in thyroid carcinomas using 2 separate BRAF monoclonal antibodies: one that detects both mutant and wild-type protein (pan-BRAF) and another that detects only the...
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