Specific immunohistochemical detection of the BRAF V600E mutation in primary and metastatic papillary thyroid carcinoma.

doi:10.1016/j.yexmp.2016.01.004

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Article

Specific immunohistochemical detection of the BRAF V600E mutation in primary and metastatic papillary thyroid carcinoma.

Experimental and molecular pathology - 1 Feb 2016

Zhu Xiaoli, Luo Yanli, Bai Qianming, Lu Yongming, Lu Yiqiong, Wu Lijing, Zhou Xiaoyan

Abstract excerpt

PURPOSE: To evaluate the clinical value of immunohistochemistry (IHC) using anti-BRAF V600E antibody (clone VE1) for specific detection of the BRAF V600E mutant protein in formalin-fixed paraffin-embedded papillary thyroid carcinoma (PTC) specimens. METHODS: A total of 118 PTC cases and 116 contr...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma
Carcinoma, Papillary
Child
DNA, Neoplasm
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Neoplasm Metastasis
Proto-Oncogene Proteins B-raf
Thyroid Cancer, Papillary
Thyroid Neoplasms

Source

Open in PubMed

Identifiers

PMID: 26795218
DOI: 10.1016/j.yexmp.2016.01.004

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-26795218-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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