Article
Value of immunohistochemistry in the detection of BRAF(V600E) mutations in fine-needle aspiration biopsies of papillary thyroid carcinoma.
Cancer cytopathology - 1 Jan 2014
Zimmermann Anne-Katrin, Camenisch Ulrike, Rechsteiner Markus P, Bode-Lesniewska Beata, Rössle Matthias
Abstract excerpt
BACKGROUND: Fine-needle aspiration biopsy (FNAB) is important in the diagnostic establishment of suspicious thyroid nodules. In thyroid neoplasms, mutation of the BRAF gene occurs rather exclusively in papillary thyroid carcinoma (PTC) and results in>98% of the cases in V600E amino acid substitut...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biopsy, Fine-Needle
- Carcinoma
- Carcinoma, Papillary
- Chi-Square Distribution
- Cohort Studies
- Confidence Intervals
- Female
- Gene Expression Regulation, Neoplastic
- High-Throughput Nucleotide Sequencing
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Proto-Oncogene Proteins B-raf