Immunohistochemistry as an accurate tool for evaluating BRAF-V600E mutation in 130 samples of papillary thyroid cancer.

doi:10.1016/j.surg.2016.06.081

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Article

Immunohistochemistry as an accurate tool for evaluating BRAF-V600E mutation in 130 samples of papillary thyroid cancer.

Surgery - 1 Apr 2017

Abd Elmageed Zakaria Y, Sholl Andrew B, Tsumagari Koji, Al-Qurayshi Zaid, Basolo Fulvio, Moroz Krzysztof, Boulares A Hamid, Friedlander Paul, Miccoli Paulo, Kandil Emad

Abstract excerpt

BACKGROUND: BRAFV600E mutation has been investigated by immunohistochemistry and has shown high sensitivity and specificity. We aim to investigate the accuracy of immunohistochemistry versus molecular testing of BRAFV600E in papillary thyroid cancer using a large number of polymerase chain reacti...

Topics

Adult
Biopsy, Needle
Carcinoma
Carcinoma, Papillary
Female
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Prognosis
Proto-Oncogene Proteins B-raf
ROC Curve

Source

Open in PubMed

Identifiers

PMID: 27919446
DOI: 10.1016/j.surg.2016.06.081

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27919446-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Sampling Studies

Sensitivity and Specificity

Thyroid Cancer, Papillary