Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression.

doi:10.1210/jc.2013-1408

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Article

Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression.

The Journal of clinical endocrinology and metabolism - 1 Aug 2013

Ghossein Ronald A, Katabi Nora, Fagin James A

Abstract excerpt

BACKGROUND: The mutated BRAF V600E protein has been specifically detected in papillary thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The clonal origin of PTCs harboring BRAF mutations has recently been called into question. OBJECTIVES: The purpose of this study was 2-fold: (1) to compare BRAF V600E IHC expression in PTCs, poorly differentiated thyroid carcinomas (PDTCs), and anaplastic...

Topics

Disease Progression
Humans
Immunohistochemistry
Mutation
Proto-Oncogene Proteins B-raf
Thyroid Neoplasms
Tissue Array Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 23775351
DOI: 10.1210/jc.2013-1408
PMCID: PMC6287446

Genes

BRAF

Variants

Provenance

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