Article
Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights.
Cancer cytopathology - 1 Oct 2015
Rossi Esther Diana, Martini Maurizio, Bizzarro Tommaso, Capodimonti Sara, Cenci Tonia, Lombardi Celestino Pio, Pontecorvi Alfredo, Fadda Guido, Larocca Luigi Maria
Abstract excerpt
BACKGROUND: Mutational analysis is reshaping the practice of fine-needle aspiration cytology for the diagnosis of thyroid nodules. The v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) valine (V) to glutamic acid (E) substitution at codon 600 (BRAF(V600E)) is the most effective diagnostic/prognostic marker and is used mainly for papillary thyroid carcinomas (PTCs). Although BRAF(V600E) represents 95% of all...
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