Article
VE1 antibody is not highly specific for the BRAF V600E mutation in thyroid cytology categories with the exception of malignant cases.
American journal of clinical pathology - 1 Mar 2015
Lee Sang-Ryung, Yim Hyunee, Han Jae Ho, Lee Kyi Beom, Lee Jeonghun, Soh Euy Young, Kim Dae Jung, Chung Yoon-Sok, Jeong Seon-Yong, Sheen Seung Soo, Park So Hyun, Kim Jang-Hee
Abstract excerpt
OBJECTIVES: We evaluated the utility of the VE1 antibody that can detect a mutant protein resulting from the BRAF V600E mutation as a diagnostic tool for thyroid fine-needle aspiration cytology (FNAC). METHODS: We performed VE1 immunocytochemistry on 202 FNAC specimens from surgically confirmed thyroid nodules. The results were compared with the molecular analyses of the BRAF mutation in these specimens matched...
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