Article
Genetic variants in human leukocyte antigen-DP influence both hepatitis C virus persistence and hepatitis C virus F protein generation in the Chinese Han population.
International journal of molecular sciences - 3 Jun 2014
Xu Xiaodong, Yue Ming, Jiang Longfeng, Deng Xiaozhao, Zhang Yongxiang, Zhang Yun, Zhu Danyan, Xiao Wen, Zhou Zhenxian, Yao Wenjuan, Kong Jing, Yu Xiaojie, Wei Juan
Abstract excerpt
Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide polymorphisms (SNPs) in a region including HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277534) and...
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