Article
Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.
Hepatology (Baltimore, Md.) - 1 May 2012
Hu Lingmin, Zhai Xiangjun, Liu Jibin, Chu Minjie, Pan Shandong, Jiang Jie, Zhang Yixin, Wang Hua, Chen Jianguo, Shen Hongbing, Hu Zhibin
Abstract excerpt
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations. More than 75% of hepatocellular carcinoma (HCC) patients are attributable to persistent infection of hepatitis B virus (HBV), especially...
Topics
- Adult
- Age Distribution
- Biopsy, Needle