Article
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
PloS one - 1 Jan 2012
Nishida Nao, Sawai Hiromi, Matsuura Kentaro, Sugiyama Masaya, Ahn Sang Hoon, Park Jun Yong, Hige Shuhei, Kang Jong-Hon, Suzuki Kazuyuki, Kurosaki Masayuki, Asahina Yasuhiro, Mochida Satoshi, Watanabe Masaaki, Tanaka Eiji, Honda Masao, Kaneko Shuichi, Orito Etsuro, Itoh Yoshito, Mita Eiji, Tamori Akihiro, Murawaki Yoshikazu, Hiasa Yoichi, Sakaida Isao, Korenaga Masaaki, Hino Keisuke, Ide Tatsuya, Kawashima Minae, Mawatari Yoriko, Sageshima Megumi, Ogasawara Yuko, Koike Asako, Izumi Namiki, Han Kwang-Hyub, Tanaka Yasuhito, Tokunaga Katsushi, Mizokami Masashi
Abstract excerpt
Hepatitis B virus (HBV) infection can lead to serious liver diseases, including liver cirrhosis (LC) and hepatocellular carcinoma (HCC); however, about 85-90% of infected individuals become inactive carriers with sustained biochemical remission and very low risk of LC or HCC. To identify host genetic factors contributing to HBV clearance, we conducted genome-wide association studies (GWAS) and replication...
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