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Article

Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.

The Journal of pathology - 1 Sept 2014

Quintás-Cardama Alfonso, Post Sean M, Solis Luisa M, Xiong Shunbin, Yang Peirong, Chen Nanyue, Wistuba Ignacio I, Killary Ann M, Lozano Guillermina

Abstract excerpt

Deregulation of cell polarity proteins has been linked to the processes of invasion and metastasis. TRIM62 is a regulator of cell polarity and a tumour suppressor in breast cancer. Here, we demonstrate that human non-small cell lung cancer lesions show a step-wise loss of TRIM62 levels during dis...

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Share to Epithelial-Mesenchymal Transition
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24890125
DOI: 10.1002/path.4385
PMCID: PMC4138305

Genes

TRIM62

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24890125-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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