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Article

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10

8 Nov 2018

Abstract excerpt

Cancer cells adopt various modes of migration during metastasis.How the ubiquitination machinery contributes to cancer cell motility remains underexplored.Here, we report that tripartite motif (TRIM) 59 is frequently up-regulated in metastatic breast cancer, which is correlated with advanced clinical stages and reduced survival among breast cancer patients.TRIM59 knockdown (KD) promoted apoptosis and inhibited...

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PMID: 30408026
DOI: 10.1371/journal.pbio.3000051

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