Article
Inhibition of breast cancer metastasis suppressor 1 promotes a mesenchymal phenotype in lung epithelial cells that express oncogenic K-RasV12 and loss of p53.
PloS one - 1 Jan 2014
Hall Emily H, Liu Yuan, Xiao Aizhen, Shock Lisa, Brautigan David L, Mayo Marty W, Adusumilli Prasad S, Jones David R
Abstract excerpt
Expression of the breast cancer metastasis suppressor 1 (BRMS1) protein is dramatically reduced in non-small cell lung cancer (NSCLC) cells and in primary human tumors. Although BRMS1 is a known suppressor of metastasis, the mechanisms through which BRMS1 functions to regulate cell migration and invasion in response to specific NSCLC driver mutations are poorly understood. To experimentally address this, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.