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Article

Synaptic function of nicastrin in hippocampal neurons.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014

Lee Sang Hun, Sharma Manu, Südhof Thomas C, Shen Jie

Abstract excerpt

Synaptic dysfunction is widely thought to play a key role in the pathogenesis of Alzheimer's disease (AD). Presenilins, the major gene products involved in familial AD, are essential for short- and long-term synaptic plasticity in mature neurons as well as for the survival of cortical neurons during aging. Presenilin and nicastrin are both indispensable components of the γ-secretase complex, but it remains...

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Identifiers

PMID: 24889619
DOI: 10.1073/pnas.1408554111
PMCID: PMC4066509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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