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Article

Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.

Aging cell - 1 Dec 2013

Sesele Katia, Thanopoulou Kalliopi, Paouri Evi, Tsefou Eliona, Klinakis Apostolos, Georgopoulos Spiros

Abstract excerpt

Production of Aβ by γ-secretase is a key event in Alzheimer's disease (AD). The γ-secretase complex consists of presenilin (PS) 1 or 2, nicastrin (ncstn), Pen-2, and Aph-1 and cleaves type I transmembrane proteins, including the amyloid precursor protein (APP). Although ncstn is widely accepted as an essential component of the complex required for γ-secretase activity, recent in vitro studies have suggested that...

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Identifiers

PMID: 23826707
DOI: 10.1111/acel.12131

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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