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Article

Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistribution.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Lu Qun, Ding Kai, Frosch Matthew P, Jones Shiloh, Wolfe Michael, Xia Weiming, Lanford George W

Abstract excerpt

Presenilin mutations are linked to the early onset familial Alzheimer's disease (FAD) and lead to a range of neuronal changes, indicating that presenilins interact with multiple cellular pathways to regulate neuronal functions. In this report, we demonstrate the effects of FAD-linked presenilin 1...

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Identifiers

PMID: 20847418
DOI: 10.3233/JAD-2010-100585
PMCID: PMC3813954

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CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20847418-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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