Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia

Abstract excerpt

BACKGROUND: Schizophrenia, a severe psychiatric disorder, has a lifetime prevalence of 1%. The exact mechanisms underlying this disorder remain unknown, though theories abound. Recent studies suggest that particular cell types and biological processes in the schizophrenic cortex have a pseudo-immature status in which the molecular properties partially resemble those in the normal immature brain. However,...

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