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Article

The microRNA-455 Null Mouse Has Memory Deficit and Increased Anxiety, Targeting Key Genes Involved in Alzheimer's Disease.

International journal of molecular sciences - 5 Jan 2022

Swingler Tracey E, Niu Lingzi, Pontifex Matthew G, Vauzour David, Clark Ian M

Abstract excerpt

The complete molecular mechanisms underlying the pathophysiology of Alzheimer's disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a circulating biomarker of early AD, with increased expression in post-mortem brain tissue of AD patients. MicroRNA-455-3p also directly targets and down-regulates APP, with the overexpression of miR-455-3p suppressing its toxic effects. Here, we...

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PMID: 35008980
DOI: 10.3390/ijms23010554
PMCID: PMC8745123

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