Article
Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion.
Endocrinology - 1 Aug 2014
Gaytan Francisco, Garcia-Galiano David, Dorfman Mauricio D, Manfredi-Lozano Maria, Castellano Juan M, Dissen Gregory A, Ojeda Sergio R, Tena-Sempere Manuel
Abstract excerpt
Premature ovarian failure (POF) affects 1% of women in reproductive age, but its etiology remains uncertain. Whereas kisspeptins, the products of Kiss1 that act via Kiss1r (aka, Gpr54), are known to operate at the hypothalamus to control GnRH/gonadotropin secretion, additional actions at other reproductive organs, including the ovary, have been proposed. Yet, their physiological relevance is still unclear. We...
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