Article
The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system.
Biochemical and biophysical research communications - 26 Dec 2003
Funes Sandrine, Hedrick Joseph A, Vassileva Galya, Markowitz Lisa, Abbondanzo Susan, Golovko Andrei, Yang Shijun, Monsma Frederick J, Gustafson Eric L
Abstract excerpt
GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological...
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