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Article

Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice.

Endocrinology - 1 Oct 2007

Lapatto Risto, Pallais J Carl, Zhang Dongsheng, Chan Yee-Ming, Mahan Amy, Cerrato Felecia, Le Wei Wei, Hoffman Gloria E, Seminara Stephanie B

Abstract excerpt

The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice demonstrate hypogonadotropic hypogonadism, but until recently, the phenotype of Kiss1 knockout mice was unknown. This report...

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Identifiers

PMID: 17595229
DOI: 10.1210/en.2007-0078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17595229-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic HypogonadismSemantic proximity Read ↗

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