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Article

The role of kisspeptin/GPR54 in the reproductive system.

In vivo (Athens, Greece) - 1 Jan 2000

Papaoiconomou E, Msaouel P, Makri A, Diamanti-Kandarakis E, Koutsilieris M

Abstract excerpt

The Kiss-1 gene encodes a secreted protein that is proteolytically cleaved to produce a number of structurally related peptides, with high interspecies conservation, globally termed kisspeptins. The original niche for the role of kisspeptin in human physiology is derived from cancer biology, with the loss of Kiss-1 expression being associated with poor prognosis in several malignancies. However, kisspeptin has...

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PMID: 21576407

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