Article
Human diseases associated with GPR54 mutations.
Progress in molecular biology and translational science - 1 Jan 2009
Teles Milena Gurgel, Silveira Leticia Ferreira Gontijo, Bianco Suzy, Latronico Ana Claudia
Abstract excerpt
G protein-coupled receptor 54 (GPR54) was first described as an orphan receptor in the rat brain one decade ago. At that time, all we knew about this receptor was that it had a high homology with other G protein-coupled receptors, like galanin receptors. Later, its endogenous ligand, kisspeptin, was identified and the kisspeptin-GPR54 system became one of the most important excitatory neuroendocrine regulators of...
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