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Article

Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.

Cancer research - 1 Jun 2014

Iwanaga Koichi, Nakamura Tatsuro, Maeda Shingo, Aritake Kosuke, Hori Masatoshi, Urade Yoshihiro, Ozaki Hiroshi, Murata Takahisa

Abstract excerpt

Compared with prostaglandin E2, which has an established role in cancer, the role of the COX metabolite prostaglandin D2 (PGD2) in chronic inflammation leading to tumorigenesis is uncertain. In this study, we investigated the role of PGD2 in colitis and colitis-associated colon cancer (CAC) using genetically modified mice and an established model of inflammatory colon carcinogenesis. Systemic genetic deficiency...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24879565
DOI: 10.1158/0008-5472.CAN-13-2792

Genes

PGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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