Article

Eosinophil-derived COX-2 protects against experimental colitis through the PGE <sub>2</sub> -IL-22 axis

2025-12-22

Abstract excerpt

Inflammatory bowel disease (IBD) is driven by a breakdown in immune regulation and epithelial barrier function, yet the contribution of eosinophils to this process has remained poorly defined and controversial. While eosinophils infiltrate the intestinal mucosa during both flares and remission, their role in shaping disease outcomes is unclear. Our RNA-seq analyses of colonic eosinophils isolated from dextran sulf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e20460b5-004b-5316-a78c-4280b60c6f58
DOI: 10.64898/2025.12.18.695257

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Eosinophil-derived COX-2 protects against experimental colitis through the PGE <sub>2</sub> -IL-22 axisDOI 10.64898/2025.12.18.695257Read

Active eosinophils regulate host defence and immune responses in colitisSemantic proximity Read

Eosinophilic Esophagitis and Inflammatory Bowel Disease: What Are the Differences?Semantic proximity Read

Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunitySemantic proximity Read

Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapySemantic proximity Read

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative ColitisSemantic proximity Read

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitisSemantic proximity Read

Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.Semantic proximity Read

Single-cell RNA sequencing unveils intestinal eosinophil development and specializationSemantic proximity Read

Differential susceptibility to colonic ulceration in mice with genetic deletion of Prostaglandin E synthaseSemantic proximity Read

Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel DiseasesSemantic proximity Read

WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in HumansSemantic proximity Read

SENP2 restrains the generation of pathogenic Th17 cells in inflammatory bowel diseaseSemantic proximity Read