Article
Deleting MyD88 signaling in myeloid cells promotes development of adenocarcinomas of the colon.
Cancer letters - 1 Oct 2018
Song Junhua, Chen Zhengtao, Geng Tingting, Wang Meixiang, Yi Shuying, Liu Kai, Zhou Wei, Gao Jiming, Song Wengang, Tang Hua
Abstract excerpt
Intestinal myeloid cells are not only essential for keeping local homeostasis, but also play an important role in regulating the occurrence of colitis and colitis-associated cancer (CAC). In these diseases, the manner in which the myeloid cells work and which molecular pathways influence them are still not fully understood. In our study, we discovered that MyD88 signaling in colonic myeloid cells participates in...
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