Article
Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells.
Nature medicine - 1 Jan 2011
Yang Xiang Dong, Ai Walden, Asfaha Samuel, Bhagat Govind, Friedman Richard A, Jin Guangchun, Park Heuijoon, Shykind Benjamin, Diacovo Thomas G, Falus Andras, Wang Timothy C
Abstract excerpt
Histidine decarboxylase (HDC), the unique enzyme responsible for histamine generation, is highly expressed in myeloid cells, but its function in these cells is poorly understood. Here we show that Hdc-knockout mice show a high rate of colon and skin carcinogenesis. Using Hdc-EGFP bacterial artifi...
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