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Article

Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in mice.

The American journal of pathology - 1 Feb 2011

Blirando Karl, Milliat Fabien, Martelly Isabelle, Sabourin Jean-Christophe, Benderitter Marc, François Agnès

Abstract excerpt

Radiation proctitis is characterized by mucosal inflammation followed by adverse chronic tissue remodeling and is associated with substantial morbidity and mortality. Mast cell hyperplasia has been associated with diseases characterized by pathological tissue remodeling and fibrosis. Rectal tissue from patients treated with radiotherapy shows mast cell hyperplasia and activation, suggesting that these cells play...

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Identifiers

PMID: 21281796
DOI: 10.1016/j.ajpath.2010.10.003
PMCID: PMC3069878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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