Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function.

The Journal of pharmacy and pharmacology - 1 Nov 2016

Liang Xin, Yin Guifang, Ma Yuanyuan, Xu Ke, Liu Jianwen, Li Jiyu

Abstract excerpt

OBJECTIVES: During colorectal tumour progression, the tumour microenvironment becomes hypoxic, and infiltration of a large number of inflammatory cells occurs. The mast cells (MCs) are a type of immune cells plays an important role in tumour angiogenesis. However, it is unclear whether the role of MC in colorectal cancer is to promote or to inhibit tumour growth. METHODS: Immunohistochemical analysis of clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenic Proteins
Share to Autocrine Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Inflammation Mediators

Share to Mast Cells

Share to Paracrine Communication

Share to Tumor Burden

Share to Tumor Microenvironment

Source

Identifiers

PMID: 27671226
DOI: 10.1111/jphp.12622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function.PMID 27671226Read ↗

SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment.Semantic proximity Read ↗

Mast Cells, microRNAs and Others: The Role of Translational Research on Colorectal Cancer in the Forthcoming Era of Precision MedicineSemantic proximity Read ↗

The role of hypoxia-inducible factor-1α on colon cancer progression and metastasisSemantic proximity Read ↗

Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer.Semantic proximity Read ↗

Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice.Semantic proximity Read ↗

Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice.Semantic proximity Read ↗

Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in mice.Semantic proximity Read ↗

CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 SignalingSemantic proximity Read ↗

Controversial role of mast cells in skin cancersSemantic proximity Read ↗

Future Needs in Mast Cell BiologySemantic proximity Read ↗

Mast cell activity in the healing wound: more than meets the eye?Semantic proximity Read ↗

A protective role of mast cells in intestinal tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.