Article
Pharmacogenomics of methadone: a narrative review of the literature.
Pharmacogenomics - 1 Aug 2020
Packiasabapathy Senthil, Aruldhas Blessed W, Horn Nicole, Overholser Brian R, Quinney Sara K, Renschler Janelle S, Sadhasivam Senthilkumar
Abstract excerpt
Background: Methadone, a synthetic opioid with longer duration of action and lower abuse potential compared with morphine, is used to prevent opioid withdrawal, as well as to manage chronic and acute surgical pain. The variability in response to methadone has been widely recognized. The purpose of this article is to review the literature on the pharmacogenetic factors underlying this variability. Materials &...
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