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Article

F-spondin deficient mice have a high bone mass phenotype.

PloS one - 1 Jan 2014

Palmer Glyn D, Attur Mukundan G, Yang Qing, Liu James, Moon Paxton, Beier Frank, Abramson Steven B

Abstract excerpt

F-spondin is a pericellular matrix protein upregulated in developing growth plate cartilage and articular cartilage during osteoarthritis. To address its function in bone and cartilage in vivo, we generated mice that were deficient for the F-spondin gene, Spon1. Spon1-/- mice were viable and developed normally to adulthood with no major skeletal abnormalities. At 6 months, femurs and tibiae of Spon1-/- mice...

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Source

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Identifiers

PMID: 24875054
DOI: 10.1371/journal.pone.0098388
PMCID: PMC4038615

Genes

SMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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