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Article

E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironment.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Yang Tao, Grafe Ingo, Bae Yangjin, Chen Shan, Chen Yuqing, Bertin Terry K, Jiang Ming-Ming, Ambrose Catherine G, Lee Brendan

Abstract excerpt

TGF-β is abundantly produced in the skeletal system and plays a crucial role in skeletal homeostasis. E-selectin ligand-1 (ESL-1), a Golgi apparatus-localized protein, acts as a negative regulator of TGF-β bioavailability by attenuating maturation of pro-TGF-β during cartilage homeostasis. However, whether regulation of intracellular TGF-β maturation by ESL-1 is also crucial during bone homeostasis has not been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23589896
DOI: 10.1073/pnas.1219748110
PMCID: PMC3645519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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