Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.

Abstract excerpt

Osteogenesis imperfecta (OI), or brittle bone disease, is most often caused by dominant mutations in the collagen I genes COL1A1/COL1A2, whereas rarer recessive OI is often caused by mutations in genes encoding collagen I-interacting proteins. Recently, mutations in the gene for the proteinase bone morphogenetic 1 (BMP1) were reported in two recessive OI families. BMP1 and the closely related proteinase mammalian...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Connective tissue disorders research
• Share to Disease Models, Animal