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Article

Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function.

Biochimica et biophysica acta - 1 Dec 2013

Erlandsson Malin C, Svensson Mattias D, Jonsson Ing-Marie, Bian Li, Ambartsumian Noona, Andersson Sofia, Peng ZhiQi, Vääräniemi Jukka, Ohlsson Claes, Andersson Karin M E, Bokarewa Maria I

Abstract excerpt

OBJECTIVE: S100A4 is a Ca-binding protein that regulates cell growth, survival, and motility. The abundant expression of S100A4 in rheumatiod arthritis contributes to the invasive growth of joint tissue and to bone damage. In the present study, we analysed the role of S100A4 in bone homeostasis. METHODS: Peripheral quantitative computed tomography and histomorphometric analysis were performed in mice lacking the...

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Source

Identifiers

PMID: 23830916
DOI: 10.1016/j.bbamcr.2013.06.020

Genes

MMP3
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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