Article
Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.
Nature - 10 Jul 2014
Karayannis T, Au E, Patel J C, Kruglikov I, Markx S, Delorme R, Héron D, Salomon D, Glessner J, Restituito S, Gordon A, Rodriguez-Murillo L, Roy N C, Gogos J A, Rudy B, Rice M E, Karayiorgou M, Hakonarson H, Keren B, Huguet G, Bourgeron T, Hoeffer C, Tsien R W, Peles E, Fishell G
Abstract excerpt
Although considerable evidence suggests that the chemical synapse is a lynchpin underlying affective disorders, how molecular insults differentially affect specific synaptic connections remains poorly understood. For instance, Neurexin 1a and 2 (NRXN1 and NRXN2) and CNTNAP2 (also known as CASPR2), all members of the neurexin superfamily of transmembrane molecules, have been implicated in neuropsychiatric...
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