CNTN4 modulates neural elongation through interplay with APP

Abstract excerpt

The neuronal cell adhesion molecule contactin-4 (CNTN4) has been genetically linked to autism spectrum disorders (ASD) and other psychiatric disorders. The Cntn4 -deficient mouse model has previously shown that CNTN4 has important roles in axon guidance and synaptic plasticity in the hippocampus. However, the pathogenesis and functional role of CNTN4 in the cortex have not yet been investigated. Using Nissl stai...

Topics

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• Autism Spectrum Disorder
• Cell Adhesion Molecules, Neuronal
• Chromosomes, Human, X
• Chromosomes, Human, Y
• HEK293 Cells
• Induced Pluripotent Stem Cells
• Intellectual Disability
• Protein Transport

Identifiers and source

Literature Corpus work

e8cffdb1-fb7b-56c9-b532-bf1fe8f974c7

DOI

10.1101/2023.08.25.554833