A subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X.

doi:10.1242/bio.061854

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X.

Biology open - 15 Jan 2025

Flores Michael A, Garcia-Forn Marta, von Mueffling Alexa, Ola Praise, Park Yeaji, Boitnott Andrea, De Rubeis Silvia

Abstract excerpt

Cell fate decisions during cortical development sculpt the identity of long-range connections that subserve complex behaviors. These decisions are largely dictated by mutually exclusive transcription factors, including CTIP2/Bcl11b for subcerebral projection neurons and BRN1/Pou3f3 for intra-telencephalic projection neurons. We have recently reported that the balance of cortical CTIP2-expressing neurons is...

Read the complete abstract on PubMed

Topics

Animals
Neurons
Mice
DEAD-box RNA Helicases
Mutation
Cerebral Cortex
Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neurogenesis

Autistic Disorder

Female

Repressor Proteins

Humans

Genetic Predisposition to Disease

Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39878593
DOI: 10.1242/bio.061854
PMCID: PMC11815569

Genes

DDX3X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X.PMID 39878593Read ↗

The determination of projection neuron identity in the developing cerebral cortex.Semantic proximity Read ↗

A network of genetic repression and derepression specifies projection fates in the developing neocortex.Semantic proximity Read ↗

ASXL3 controls cortical neuron fate specification through extrinsic self-renewal pathwaysSemantic proximity Read ↗

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.Semantic proximity Read ↗

A microRNA cluster downstream of the selector gene Fezf2 coordinates fate specification with dendritic branching in cortical neuronsSemantic proximity Read ↗

Prospective separation and transcriptome analyses of cortical projection neurons and interneurons based on lineage tracing by Tbr2 (Eomes)-GFP/Dcx-mRFP reporters.Semantic proximity Read ↗

Disruption of the transcription factor <i>NEUROD2</i> causes an autism syndrome via cell-autonomous defects in cortical projection neuronsSemantic proximity Read ↗

Intellectual disability risk gene RFX4 regulates cortical neurogenesis by restraining neuronal differentiationSemantic proximity Read ↗

Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways.Semantic proximity Read ↗

Developmental and behavioral phenotypes in a new mouse model of DDX3X syndromeSemantic proximity Read ↗

Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity.Semantic proximity Read ↗

The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.