Article
Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups.
Oncotarget - 15 May 2014
Simbolo Michele, Fassan Matteo, Ruzzenente Andrea, Mafficini Andrea, Wood Laura D, Corbo Vincenzo, Melisi Davide, Malleo Giuseppe, Vicentini Caterina, Malpeli Giorgio, Antonello Davide, Sperandio Nicola, Capelli Paola, Tomezzoli Anna, Iacono Calogero, Lawlor Rita T, Bassi Claudio, Hruban Ralph H, Guglielmi Alfredo, Tortora Giampaolo, de Braud Filippo, Scarpa Aldo
Abstract excerpt
One-hundred-fifty-three biliary cancers, including 70 intrahepatic cholangiocarcinomas (ICC), 57 extrahepatic cholangiocarcinomas (ECC) and 26 gallbladder carcinomas (GBC) were assessed for mutations in 56 genes using multigene next-generation sequencing. Expression of EGFR and mTOR pathway genes was investigated by immunohistochemistry. At least one mutated gene was observed in 118/153 (77%) cancers. The genes...
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