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Article

Large-scale analysis reveals a functional single-nucleotide polymorphism in the 5'-flanking region of PRDM16 gene associated with lean body mass.

Aging cell - 1 Aug 2014

Urano Tomohiko, Shiraki Masataka, Sasaki Noriko, Ouchi Yasuyoshi, Inoue Satoshi

Abstract excerpt

Genetic factors are important for the development of sarcopenia, a geriatric disorder characterized by low lean body mass. The aim of this study was to search for novel genes that regulate lean body mass in humans. We performed a large-scale search for 250K single-nucleotide polymorphisms (SNPs) associated with bone mineral density (BMD) using SNP arrays in 1081 Japanese postmenopausal women. We focused on an SNP...

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Identifiers

PMID: 24863034
DOI: 10.1111/acel.12228
PMCID: PMC4326941

Genes

PRDM16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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