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Association of a Trp16Ser variation in the gonadotropin releasing hormone signal peptide with bone mineral density, revealed by SNP-dependent PCR typing.

Bone - 1 Feb 2003

Iwasaki Hironori, Emi Mitsuru, Ezura Yoichi, Ishida Ryota, Kajita Mitsuko, Kodaira Mina, Yoshida Hideyo, Suzuki Takao, Hosoi Takayuki, Inoue Satoshi, Shiraki Masataka, Swensen Jeff, Orimo Hajime

Abstract excerpt

Osteoporosis is believed to result from interplay among multiple environmental and genetic determinants, including factors that regulate bone mineral density (BMD). Among those factors, adequate estrogen is essential for achievement of peak bone mass as well as for postmenopausal maintenance of skeletal homeostasis. Gonadotropin-releasing hormone (GnRH) from the hypothalamus is the primary determinant in the...

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PMID: 12633791
DOI: 10.1016/s8756-3282(02)00949-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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