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Article

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.

The Journal of biological chemistry - 13 Mar 2015

Marinangeli Claudia, Tasiaux Bernadette, Opsomer Rémi, Hage Salim, Sodero Alejandro O, Dewachter Ilse, Octave Jean Noël, Smith Steven O, Constantinescu Stefan N, Kienlen-Campard Pascal

Abstract excerpt

Understanding the molecular mechanisms controlling the physiological and pathological activity of γ-secretase represents a challenging task in Alzheimer disease research. The assembly and proteolytic activity of this enzyme require the correct interaction of the 19 transmembrane domains (TMDs) present in its four subunits, including presenilin (PS1 or PS2), the γ-secretase catalytic core. GXXXG and GXXXG-like...

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Identifiers

PMID: 25614624
DOI: 10.1074/jbc.M114.601286
PMCID: PMC4358137

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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