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Article

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.

The Journal of biological chemistry - 17 Dec 2004

Westmeyer Gil G, Willem Michael, Lichtenthaler Stefan F, Lurman Glenn, Multhaup Gerd, Assfalg-Machleidt Irmgard, Reiss Karina, Saftig Paul, Haass Christian

Abstract excerpt

Cleavage of the beta-amyloid precursor protein (APP) by the aspartyl protease beta-site APP-cleaving enzyme (BACE) is the first step in the generation of the amyloid beta-peptide, which is deposited in the brain of Alzheimer's disease patients. Whereas the subsequent cleavage by gamma-secretase was shown to originate from the cooperation of a multicomponent complex, it is currently unknown whether in a cellular...

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Source

Identifiers

PMID: 15485862
DOI: 10.1074/jbc.M410378200

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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