Article
The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death.
Molecular and cellular neurosciences - 1 Jul 2014
Cameron Ryan T, Quinn Steven D, Cairns Lynn S, MacLeod Ruth, Samuel Ifor D W, Smith Brian O, Carlos Penedo J, Baillie George S
Abstract excerpt
Up-regulation of Hsp20 protein levels in response to amyloid fibril formation is considered a key protective response against the onset of Alzheimer's disease (AD). Indeed, the physical interaction between Hsp20 and Aβ is known to prevent Aβ oligomerisation and protects neuronal cells from Aβ mediated toxicity, however, details of the molecular mechanism and regulatory cell signalling events behind this process...
Topics
- Amyloid beta-Peptides
- Arginine
- Cell Death
- Cell Line, Tumor
- Dose-Response Relationship, Drug
- HSP20 Heat-Shock Proteins
- Humans
- Immunoprecipitation
- Magnetic Resonance Spectroscopy
- Mutation
- Neuroblastoma
- Peptide Fragments
- Peptide Mapping