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The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of β‐amyloid peptide

15 Jun 2009

Abstract excerpt

Neurofibrillary tangles and amyloid plaques are considered to be hallmarks of Alzheimer's disease (AD), and the toxic effects of amyloid-beta peptide (A beta) lead to activation of stress-related signaling and neuronal loss. The small heat shock protein Hsp27 is reported to be increased in AD brains and to accumulate in plaques, but whether this represents a potentially protective response to stress or is part of...

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PMID: 19530165
DOI: 10.1002/jnr.22145

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