Article
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
Molecular pharmacology - 1 Dec 2015
Xiong Rui, Zhou Wenbo, Siegel David, Kitson Russell R A, Freed Curt R, Moody Christopher J, Ross David
Abstract excerpt
A potential cause of neurodegenerative diseases, including Parkinson's disease (PD), is protein misfolding and aggregation that in turn leads to neurotoxicity. Targeting Hsp90 is an attractive strategy to halt neurodegenerative diseases, and benzoquinone ansamycin (BQA) Hsp90 inhibitors such as geldanamycin (GA) and 17-(allylamino)-17-demethoxygeldanamycin have been shown to be beneficial in mutant A53T...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.